nejm-rebuttal
GitHub用于处理NEJM审稿意见的回复技能。首先解读编辑决定与关键要求，特别针对统计审稿人进行严谨的数据重算与回应。将评论分为四类处理，按指定格式逐条撰写包含原文引用、回复及修改文本的点对点回复信。
Trigger Scenarios
Install
npx skills add brycewang-stanford/Awesome-Journal-Skills --skill nejm-rebuttal -g -y
SKILL.md
Frontmatter
{
"name": "nejm-rebuttal",
"description": "Use after NEJM reviews arrive — often including a dedicated statistical reviewer and an editor letter — to triage the decision, answer statistical comments rigorously, and draft a point-by-point response that quotes each comment, the response, and the revised manuscript text. Do not run before the main text is actually revised."
}
Response to Reviewers (nejm-rebuttal)
When to trigger
- A decision letter arrives (reject / reject-but-resubmit / major or minor revision).
- You have reviewer comments — frequently including a statistical reviewer — and need a strategy.
- A revision is drafted and you need the point-by-point response letter.
Step 0: read the editor's letter first
The editor's framing outranks individual reviewers. Identify:
- The decision type and whether a new review round is implied.
- Which concerns the editor emphasizes (these are load-bearing — address fully).
- Any deal-breaker the editor names (e.g., "the primary analysis must be ITT", "registration discrepancy must be resolved").
A "reject but would consider a new submission" is an invitation gated on the deal-breaker. Do not treat it as a flat reject, and do not under-deliver.
The statistical reviewer is special
NEJM commonly assigns a statistician whose comments carry decisive weight and require rigorous statistical responses, not prose:
- Re-run analyses exactly as requested (ITT vs per-protocol, multiplicity adjustment, alternative models, sensitivity analyses) and show the numbers with CIs.
- If asked about subgroup over-interpretation, report the interaction test and reframe the subgroup as exploratory.
- For missing data, demonstrate robustness (e.g., results under multiple imputation vs complete case).
- Concede a methodological point with the corrected analysis rather than defending a weaker one.
- Loop in
nejm-statisticsto make sure every re-analysis is reported to NEJM's standard.
Triage every comment into 4 buckets
| Bucket | Action |
|---|---|
| Do (fair, feasible) | Make the change; show it; quote the new text/table/figure. |
| Do-partial | Do what's feasible; explain the boundary with evidence. |
| Defend (wrong/out of scope) | Push back respectfully, with data/citations — not assertion. |
| Defer (future work) | Acknowledge; add a sentence to the text; don't over-promise. |
Most rejections-on-revision come from silently skipping a load-bearing comment or defending when a re-analysis was actually needed.
Response-letter format
For each comment:
Reviewer N, Comment k: <verbatim quote of the reviewer>
Response: <what we did / our reasoning>. <Evidence: re-analysis with effect + 95% CI,
new Table/Fig., updated CONSORT numbers.>
Changes: "<quoted new manuscript text>" (p. X, lines Y–Z; Table/Fig. update).
- Open with a short thank-you and a 3–4 line summary of the major changes across the revision.
- Quote each comment verbatim; never paraphrase in a way that softens the reviewer's point.
- Quote the new manuscript text so the editor and statistician can verify without hunting.
- Use a consistent visual convention (reviewer text plain, response indented, manuscript quotes in italics).
Over-claiming and causation watch (NEJM-specific)
If a reviewer says the conclusion outruns the data — or that causal language is used on observational data — this is the most dangerous comment for a clinical paper. Either add the evidence or narrow the claim in the abstract Conclusions, title, and Discussion, and soften causal verbs to associations where appropriate. Be honest about limitations; a candid limitations paragraph builds credibility. Re-run nejm-fit if the narrowed claim weakens the practice-changing case.
Output format
【Decision type】 reject / reject-resubmit / major / minor
【Editor's load-bearing concerns】 [...]
【Deal-breaker】 ... → plan to resolve
【Statistical reviewer comments】 [...] → re-analyses planned (with CIs)
【Comment triage】 Do [...] / Do-partial [...] / Defend [...] / Defer [...]
【Claim integrity】 over-claiming / causal-language narrowing needed? (re-check nejm-fit)
【Response letter】 drafted point-by-point with quoted changes
Anti-patterns
- Do not silently skip a comment the editor emphasized.
- Do not answer a statistical reviewer with prose where a re-analysis with CIs is required.
- Do not defend causal language on observational data — narrow it to association.
- Do not over-promise future work to dodge a needed re-analysis.
- Do not draft the response before the manuscript is actually revised.
Version History
- 1839142 Current 2026-07-05 14:05
