Agent Skills
› openai/plugins
› gtex-eqtl-skill
gtex-eqtl-skill
GitHub通过rsID、GRCh37或GRCh38坐标查询GTEx单组织eQTL关联数据。自动解析变体格式并转换为GRCh38查询，返回JSON结果。
Trigger Scenarios
用户需要获取特定基因变异的eQTL关联信息
输入包含rsID或基因组坐标（如chr-pos-ref-alt）
需要将变体ID转换为GTEx v2 API所需格式
Install
npx skills add openai/plugins --skill gtex-eqtl-skill -g -y
SKILL.md
Frontmatter
{
"name": "gtex-eqtl-skill",
"description": "Fetch GTEx single-tissue eQTL associations from one variant input by accepting rsID, GRCh37, or GRCh38 input and resolving to the required GRCh38 query for the GTEx v2 API. Use when a user wants eQTL associations returned as JSON."
}
Operating rules
- Use Python
requestsfor all network calls. - Accept exactly one of
rsid,grch37,grch38, orvariant, and resolve to a GRCh38chrom-pos-ref-altquery. - Convert to GTEx
variantIdformat:chr{chrom}_{pos}_{ref}_{alt}_b38. - Always return one JSON object (no markdown) as final output.
Input
Accept JSON on stdin as either:
- A string:
"10-112998590-C-T"(treated as GRCh38) - An object:
{
"grch38": "10-112998590-C-T",
"max_results": 200
}
Other accepted object forms include:
{
"grch37": "10-114758349-C-T"
}
{
"rsid": "rs7903146",
"max_results": 50
}
Allowed variant separators include -, :, _, /, or whitespace, for example:
10-112998590-C-T10:112998590-C-T10:112998590:C:Tchr10 112998590 C T
max_results is optional and truncates returned eQTL rows when provided.
Output
Success shape:
{
"ok": true,
"source": "gtex-v2",
"input": {"type": "grch38", "value": "10-112998590-C-T"},
"query_variant": {
"chr": "10",
"pos": 112998590,
"ref": "C",
"alt": "T",
"canonical": "10:112998590-C-T",
"variant_id": "chr10_112998590_C_T_b38"
},
"eqtl_count": 2,
"eqtl_count_total": 2,
"truncated": false,
"eqtls": [],
"paging_info": {},
"warnings": []
}
Failure shape:
{
"ok": false,
"error": {"code": "...", "message": "..."},
"warnings": []
}
Execution
Use:
scripts/gtex_eqtl.py
The script reads JSON from stdin and prints JSON to stdout.
Example:
echo '{"grch38":"10-112998590-C-T","max_results":5}' | python scripts/gtex_eqtl.py
Version History
- 11c74d6 Current 2026-07-19 09:38
