Agent Skills
› companion-inc/feynman
› solublempnn
solublempnn
GitHub用于基于SolubleMPNN工作流进行溶解度感知蛋白质设计、筛选及表达友好型变体生成。涵盖输入记录、模型执行、结果保存及针对疏水斑块等特征的候选序列过滤，并附实验建议。
触发场景
需要设计或筛选具有溶解度约束的蛋白质序列
生成表达友好的蛋白质变体
评估蛋白质溶解度风险
安装
npx skills add companion-inc/feynman --skill solublempnn -g -y
SKILL.md
Frontmatter
{
"name": "solublempnn",
"description": "Design or screen protein sequences for solubility-aware constraints with SolubleMPNN-style workflows. Use when a task asks for soluble protein design, expression-friendly variants, or solubility risk filtering."
}
SolubleMPNN
Use this skill for solubility-aware protein design.
Workflow:
- Record input structure or sequence, design positions, expression system, forbidden motifs, and stability/solubility constraints.
- Verify model availability and execution path before running.
- Save input files, masks, command, model version, generated sequences, scores, and filtering tables.
- Filter candidates for hydrophobic patches, charge balance, repeats, liabilities, conservation, and structure-confidence impact.
- Attach assay or expression-screen recommendations when a decision depends on solubility.
Do not equate a solubility score with confirmed expression.
版本历史
- 54d08a3 当前 2026-07-25 07:16
