Agent Skills › companion-inc/feynman › borzoi

borzoi

GitHub

用于非编码变异影响、调控序列设计及表达预测的监管基因组建模技能。涵盖固定基因组构建、确认模型路由、构建输入数据、保存预测结果及对比证据等标准化工作流。

skills/borzoi/SKILL.md companion-inc/feynman

触发场景

需要分析非编码变异的影响进行调控序列设计执行基因表达预测任务

安装

npx skills add companion-inc/feynman --skill borzoi -g -y

更多选项

不安装直接使用

npx skills use companion-inc/feynman@borzoi

指定 Agent (Claude Code)

npx skills add companion-inc/feynman --skill borzoi -a claude-code -g -y

安装 repo 全部 skill

npx skills add companion-inc/feynman --all -g -y

预览 repo 内 skill

npx skills add companion-inc/feynman --list

SKILL.md

Frontmatter

{
    "name": "borzoi",
    "description": "Use Borzoi-style regulatory genomics models for sequence-to-expression or variant-effect analysis. Use when the task asks for noncoding variant impact, regulatory sequence design, or expression prediction."
}

Borzoi

Use this skill for regulatory genomics modeling around sequence, variant, and expression effects.

Workflow:

Pin genome build, interval coordinates, reference/alternate alleles, cell type or tissue, strand, and window size.
Confirm the model route: local checkpoint, managed endpoint, notebook package, or external documented service. Record missing checkpoints as setup work, not as a completed model run.
Build input FASTA/variant manifests with source URLs or accession IDs.
Save prediction arrays, summary tables, plots, model version, and runtime metadata as Feynman artifacts.
Compare predicted effects against GTEx, ENCODE, literature, or other source-backed evidence when available.

Keep source-owned genomic coordinates separate from model-owned effect predictions in every output.