Agent Skills › companion-inc/feynman › solublempnn

solublempnn

GitHub

用于基于SolubleMPNN工作流进行溶解度感知蛋白质设计、筛选及表达友好型变体生成。涵盖输入记录、模型执行、结果保存及针对疏水斑块等特征的候选序列过滤，并附实验建议。

skills/solublempnn/SKILL.md companion-inc/feynman

Trigger Scenarios

需要设计或筛选具有溶解度约束的蛋白质序列生成表达友好的蛋白质变体评估蛋白质溶解度风险

Install

npx skills add companion-inc/feynman --skill solublempnn -g -y

More Options

Use without installing

npx skills use companion-inc/feynman@solublempnn

指定 Agent (Claude Code)

npx skills add companion-inc/feynman --skill solublempnn -a claude-code -g -y

安装 repo 全部 skill

npx skills add companion-inc/feynman --all -g -y

预览 repo 内 skill

npx skills add companion-inc/feynman --list

SKILL.md

Frontmatter

{
    "name": "solublempnn",
    "description": "Design or screen protein sequences for solubility-aware constraints with SolubleMPNN-style workflows. Use when a task asks for soluble protein design, expression-friendly variants, or solubility risk filtering."
}

SolubleMPNN

Use this skill for solubility-aware protein design.

Workflow:

Record input structure or sequence, design positions, expression system, forbidden motifs, and stability/solubility constraints.
Verify model availability and execution path before running.
Save input files, masks, command, model version, generated sequences, scores, and filtering tables.
Filter candidates for hydrophobic patches, charge balance, repeats, liabilities, conservation, and structure-confidence impact.
Attach assay or expression-screen recommendations when a decision depends on solubility.

Do not equate a solubility score with confirmed expression.