Agent Skills
› Companion-Inc/feynman
› solublempnn
solublempnn
GitHub用于基于SolubleMPNN进行蛋白质序列的可溶性设计与筛选。涵盖记录输入约束、验证模型、生成序列及过滤候选者，旨在设计表达友好且可溶性高的蛋白变体，并评估表达风险。
Trigger Scenarios
需要设计高可溶性蛋白质序列
筛选具有良好表达潜力的蛋白变体
评估蛋白质设计的可溶性风险
Install
npx skills add Companion-Inc/feynman --skill solublempnn -g -y
SKILL.md
Frontmatter
{
"name": "solublempnn",
"description": "Design or screen protein sequences for solubility-aware constraints with SolubleMPNN-style workflows. Use when a task asks for soluble protein design, expression-friendly variants, or solubility risk filtering."
}
SolubleMPNN
Use this skill for solubility-aware protein design.
Workflow:
- Record input structure or sequence, design positions, expression system, forbidden motifs, and stability/solubility constraints.
- Verify model availability and execution path before running.
- Save input files, masks, command, model version, generated sequences, scores, and filtering tables.
- Filter candidates for hydrophobic patches, charge balance, repeats, liabilities, conservation, and structure-confidence impact.
- Attach assay or expression-screen recommendations when a decision depends on solubility.
Do not equate a solubility score with confirmed expression.
Version History
- 54d08a3 Current 2026-07-25 07:16
