Agent Skills › companion-inc/feynman › solublempnn

solublempnn

GitHub

用于基于SolubleMPNN工作流进行溶解度感知的蛋白质设计与筛选。涵盖输入记录、模型验证、序列生成及针对疏水斑块等特征的候选者过滤，旨在设计易表达或降低溶解度风险的蛋白变体。

skills/solublempnn/SKILL.md companion-inc/feynman

Trigger Scenarios

需要设计具有特定溶解度的蛋白质序列筛选表达友好的蛋白变体评估并过滤存在溶解度风险的蛋白候选项

Install

npx skills add companion-inc/feynman --skill solublempnn -g -y

More Options

Use without installing

npx skills use companion-inc/feynman@solublempnn

指定 Agent (Claude Code)

npx skills add companion-inc/feynman --skill solublempnn -a claude-code -g -y

安装 repo 全部 skill

npx skills add companion-inc/feynman --all -g -y

预览 repo 内 skill

npx skills add companion-inc/feynman --list

SKILL.md

Frontmatter

{
    "name": "solublempnn",
    "description": "Design or screen protein sequences for solubility-aware constraints with SolubleMPNN-style workflows. Use when a task asks for soluble protein design, expression-friendly variants, or solubility risk filtering."
}

SolubleMPNN

Use this skill for solubility-aware protein design.

Workflow:

Record input structure or sequence, design positions, expression system, forbidden motifs, and stability/solubility constraints.
Verify model availability and execution path before running.
Save input files, masks, command, model version, generated sequences, scores, and filtering tables.
Filter candidates for hydrophobic patches, charge balance, repeats, liabilities, conservation, and structure-confidence impact.
Attach assay or expression-screen recommendations when a decision depends on solubility.

Do not equate a solubility score with confirmed expression.