Agent Skills
› companion-inc/feynman
› borzoi
borzoi
GitHub用于非编码变异影响、调控序列设计及表达预测的基因组建模技能，支持从FASTA输入到结果对比的全流程。
Trigger Scenarios
询问非编码变异的影响
需要设计调控序列
进行基因表达预测
Install
npx skills add companion-inc/feynman --skill borzoi -g -y
SKILL.md
Frontmatter
{
"name": "borzoi",
"description": "Use Borzoi-style regulatory genomics models for sequence-to-expression or variant-effect analysis. Use when the task asks for noncoding variant impact, regulatory sequence design, or expression prediction."
}
Borzoi
Use this skill for regulatory genomics modeling around sequence, variant, and expression effects.
Workflow:
- Pin genome build, interval coordinates, reference/alternate alleles, cell type or tissue, strand, and window size.
- Confirm the model route: local checkpoint, managed endpoint, notebook package, or external documented service. Record missing checkpoints as setup work, not as a completed model run.
- Build input FASTA/variant manifests with source URLs or accession IDs.
- Save prediction arrays, summary tables, plots, model version, and runtime metadata as Feynman artifacts.
- Compare predicted effects against GTEx, ENCODE, literature, or other source-backed evidence when available.
Keep source-owned genomic coordinates separate from model-owned effect predictions in every output.
Version History
- 54d08a3 Current 2026-07-25 07:15
