Agent Skills › advaitpaliwal/feynman › borzoi

borzoi

GitHub

用于非编码变异效应分析、调控序列设计及表达预测的基因组建模技能。通过固定基因组参数、选择模型路径并构建输入数据，生成预测结果并与公开数据库比对验证。

skills/borzoi/SKILL.md advaitpaliwal/feynman

Trigger Scenarios

非编码变异影响分析调控序列设计基因表达预测

Install

npx skills add advaitpaliwal/feynman --skill borzoi -g -y

More Options

Use without installing

npx skills use advaitpaliwal/feynman@borzoi

指定 Agent (Claude Code)

npx skills add advaitpaliwal/feynman --skill borzoi -a claude-code -g -y

安装 repo 全部 skill

npx skills add advaitpaliwal/feynman --all -g -y

预览 repo 内 skill

npx skills add advaitpaliwal/feynman --list

SKILL.md

Frontmatter

{
    "name": "borzoi",
    "description": "Use Borzoi-style regulatory genomics models for sequence-to-expression or variant-effect analysis. Use when the task asks for noncoding variant impact, regulatory sequence design, or expression prediction."
}

Borzoi

Use this skill for regulatory genomics modeling around sequence, variant, and expression effects.

Workflow:

Pin genome build, interval coordinates, reference/alternate alleles, cell type or tissue, strand, and window size.
Confirm the model route: local checkpoint, managed endpoint, notebook package, or external documented service. Record missing checkpoints as setup work, not as a completed model run.
Build input FASTA/variant manifests with source URLs or accession IDs.
Save prediction arrays, summary tables, plots, model version, and runtime metadata as Feynman artifacts.
Compare predicted effects against GTEx, ENCODE, literature, or other source-backed evidence when available.

Keep source-owned genomic coordinates separate from model-owned effect predictions in every output.