Agent Skills
› companion-inc/feynman
› proteinmpnn
proteinmpnn
GitHub用于固定骨架蛋白质序列设计的技能，支持突变建议、固定残基及设计过滤。涵盖从结构输入到候选序列验证的完整工作流，强调结果需经结构与实验验证。
Trigger Scenarios
需要基于固定骨架进行蛋白质序列设计
请求突变建议或固定残基处理
涉及蛋白质设计结果的过滤与筛选
Install
npx skills add companion-inc/feynman --skill proteinmpnn -g -y
SKILL.md
Frontmatter
{
"name": "proteinmpnn",
"description": "Design protein sequences from fixed backbone structures with ProteinMPNN-style workflows. Use when a task asks for backbone-conditioned sequence design, mutation suggestions, fixed residues, or design filtering."
}
ProteinMPNN
Use this skill for fixed-backbone protein sequence design.
Workflow:
- Record input structure, chain ids, designed positions, fixed residues, tied positions, symmetry, and design objective.
- Verify the local or remote execution route before running.
- Save PDB/mmCIF inputs, design masks, command, seeds, model version, FASTA outputs, and score tables.
- Filter designs by constraints, diversity, motifs, structure prediction, conservation, and assay-ready feasibility.
- Attach provenance and a verification plan before recommending candidates.
Treat generated sequences as candidates that require structural and experimental validation.
Version History
- 54d08a3 Current 2026-07-25 07:16
