Agent Skills › advaitpaliwal/feynman › solublempnn

solublempnn

GitHub

用于溶解度感知蛋白质设计的技能，涵盖序列设计、表达友好变体生成及风险过滤。执行时记录约束条件，验证模型，保存中间文件与结果，并基于理化特性筛选候选序列，提供实验建议。

skills/solublempnn/SKILL.md advaitpaliwal/feynman

Trigger Scenarios

需要进行溶解度感知的蛋白质序列设计寻找表达友好的蛋白质变体执行溶解度风险评估与过滤

Install

npx skills add advaitpaliwal/feynman --skill solublempnn -g -y

More Options

Use without installing

npx skills use advaitpaliwal/feynman@solublempnn

指定 Agent (Claude Code)

npx skills add advaitpaliwal/feynman --skill solublempnn -a claude-code -g -y

安装 repo 全部 skill

npx skills add advaitpaliwal/feynman --all -g -y

预览 repo 内 skill

npx skills add advaitpaliwal/feynman --list

SKILL.md

Frontmatter

{
    "name": "solublempnn",
    "description": "Design or screen protein sequences for solubility-aware constraints with SolubleMPNN-style workflows. Use when a task asks for soluble protein design, expression-friendly variants, or solubility risk filtering."
}

SolubleMPNN

Use this skill for solubility-aware protein design.

Workflow:

Record input structure or sequence, design positions, expression system, forbidden motifs, and stability/solubility constraints.
Verify model availability and execution path before running.
Save input files, masks, command, model version, generated sequences, scores, and filtering tables.
Filter candidates for hydrophobic patches, charge balance, repeats, liabilities, conservation, and structure-confidence impact.
Attach assay or expression-screen recommendations when a decision depends on solubility.

Do not equate a solubility score with confirmed expression.